When converting a design to a DotNetNuke skin the fonts are always a subject of high importance. The known standard web fonts supported by all browsers in all platforms is quite limited so we either have to replace fonts with something more standard or have to find a way to include the fonts in the web.
Google Web Fonts is a nice option but you are limited to the list of fonts available online (+400 at the time of writing). So if you need a special font not available on Google’s list you are out of luck.